Quinolines and derivatives
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Filtered Search Results
Medchemexpress LLC Everolimus | 159351-69-6 | MFCD00929329 | 99.7% | 958.22 g/mol | C53H83NO14 | 200 MG
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Everolimus is a rapamycin-derivative mTORC1 inhibitor used in research to modulate cell growth, proliferation, autophagy, and immune responses. It binds FKBP12 to form an inhibitory complex with mTOR and is commonly used in cellular and preclinical studies.
- Potent, selective mTORC1 inhibitor.
- Binds FKBP12 to form an inhibitory complex with mTOR.
- High purity reported (99.74%).
- Available in multiple research pack sizes up to 100 mg and as a 10 mM solution.
- Intended for research and analytical applications.
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ARCTOM SCIENTIFIC E-1-PIPERIDINO-3-3-QUINOLIN
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NC3720322 E-1-PIPERIDINO-3-3-QUINOLIN
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Apexbio Technology LLC Palifosfamide 31645-39-3 200mg
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Palifosfamide (CAS 31645-39-3) is the active metabolite derivative of ifosfamide (IFA) an alkylating agent exhibiting cytotoxic effects through cross-linking DNA strands thereby interfering with replication and transcription Palifosfamide lysine demonstrates anticancer activity against pediatric sarcoma cell lines including osteosarcoma models such as SAOS-2 (IC50 2 25 6 75 M) and decreased sensitivity in OS222 (IC50 31 5 M) In murine xenograft experiments (MX-1 tumors) palifosfamide treatment at 100 mg/kg showed substantial tumor growth inhibition ( 80%) and partial complete response rates ( 17%) highlighting its applicability in preclinical oncology research
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eMolecules EMOLECULES INC
5000483323 7-BROMOISOQUINOLINE 5G
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eMolecules EMOLECULES INC
5000472838 6-FLUORO-2-METHYLQUINOLINE 1G
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Apexbio Technology LLC NVP-BSK805 2HCl 1092499-93-8 (free base) 200mg
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NVP-BSK805 2HCl is a selective ATP-competitive inhibitor targeting Janus kinase 2 (JAK2) JAK2 part of the JAK kinase family mediates signaling through cytokine receptor systems including type II cytokine GM-CSF receptor gp130 and single-chain receptor families By competitively binding the ATP-binding site of JAK2 NVP-BSK805 inhibits downstream STAT5 phosphorylation and JAK-mediated signaling It displays greater than 20-fold selectivity for JAK2 versus other JAK family members (JAK1 JAK3 TYK2) Cell-based assays demonstrate antiproliferative activity against cells expressing JAK2V617F mutations NVP-BSK805 is commonly employed in vitro and in vivo to investigate JAK2-mediated cellular responses oncogenesis and associated signaling pathways
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Apexbio Technology LLC Rucaparib (AG-014699,PF-01367338) 459868-92-9 200mg
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Rucaparib (AG-014699 PF-01367338 CAS 459868-92-9) is a small molecule inhibitor targeting poly(ADP-ribose) polymerase (PARP) a nuclear enzyme activated by DNA damage and central to the base excision repair pathway By blocking PARP activity rucaparib impairs DNA repair especially in cells with pre-existing DNA repair deficiencies such as those induced by genotoxic stress In prostate cancer research rucaparib induces radiosensitization notably in PTEN-deficient cells expressing ETS fusion proteins through inhibition of non-homologous end joining (NHEJ) It is thus relevant in studies investigating DNA damage response pathways cancer biology and therapeutic radiosensitization strategies
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Apexbio Technology LLC Baricitinib (LY3009104, INCB028050) 1187594-09-7 200mg
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Baricitinib (LY3009104 INCB028050 CAS 1187594-09-7) is an orally bioavailable ATP-competitive inhibitor targeting Janus kinases JAK1 and JAK2 It also exhibits moderate inhibition of TYK2 and weaker inhibition against JAK3 In biochemical assays baricitinib inhibits JAK1 and JAK2 with IC50 values of 5 9 nM and 5 7 nM respectively At concentrations below 50 nM baricitinib suppresses intracellular signaling mediated by several pro-inflammatory cytokines notably IL-6 and IL-23 Due to its mechanistic profile baricitinib is actively explored in inflammatory disease research such as rheumatoid arthritis
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eMolecules EMOLECULES INC
5000489037 2-BROMONAPHTHALEN-1-AMINE 1G
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eMolecules ChemScene Methyl 2-(quinolin-6-yl)acetate 250mg 569143724 CS-0019231 0 000 5622-36-6 MFCD04038669 201 225 C12H11NO2
ChemScene Methyl 2-(quinolin-6-yl)acetate 250mg 569143724 CS-0019231 0 000 5622-36-6 MFCD04038669 201 225 C12H11NO2
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Medchemexpress LLC CP 339818 hydrochloride | 478341-55-8 | 99.6% | 340.89 g/mol | C21H25ClN2 | 5 MG
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CP 339818 hydrochloride is a small-molecule, non-peptide ion-channel inhibitor used in electrophysiology and pharmacology research. It blocks Kv1.3 and Kv1.4 channels and inhibits HCN channels, making it useful for studying Kv- and HCN-mediated currents and T-cell activation.
- Non-peptide Kv1.3 and Kv1.4 channel blocker.
- Inhibits HCN channel isoforms with micromolar potency.
- High-purity white to off-white solid suitable for research use.
- Soluble in DMSO up to 62.5 mg/mL.
- Store sealed at 4°C; in solution, keep at -80°C (up to 6 months) or -20°C (up to 1 month).
- Molecular weight 340.89 g/mol; formula C21H25ClN2.
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Sigma Aldrich Fine Chemicals Biosciences Lomefloxacin hydrochloride | 98079-52-8 | MFCD00214312 | 1G
Lomefloxacin hydrochloride | Mol Wt: 387.81 | 98079-52-8 | MFCD00214312 | 1G
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Sigma Aldrich Fine Chemicals Biosciences Mefloquine hydrochloride European Pharmacopoeia (EP) Reference Standard | 51773-92-3 | MFCD00797519 |
Mefloquine hydrochloride European Pharmacopoeia (EP) Reference Standard | Mol Wt: 414.77 | 51773-92-3 | MFCD00797519 |
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eMolecules EMOLECULES INC
5000472229 2-METHOXYPYRIDINE-4-CARBA 2.5G
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Sigma Aldrich Fine Chemicals Biosciences 2-Hydroxyquinoline 98% | 59-31-4 | MFCD00006743 | 1G
2-Hydroxyquinoline 98% | Purity: 98% | Mol Wt: 145.16 | 59-31-4 | MFCD00006743 | 1G
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